Generic protocol for estimating the burden of Pertussis in young children

The primary objective of this protocol is to estimate the incidence and disease burden of pertussis in children under 5 years of age during periods of low to high (outbreak) disease activity. This will be achieved by a modular approach using three methodologies:- Ongoing enhanced passive surveillance - Community-based survey through cluster sampling - Outbreak investigation. The secondary objectives are to estimate 1. the incidence, hospitalization, and case fatality rates of pertussis in infants less than 12 months of age and 2. the efficcy any of a single dose of pertussis vaccine (given on time) to protect against death.