Invasive disease potential of pneumococci before and after the 13-valent pneumococcal conjugate vaccine implementation in children

Highlights

•Before and after PCV13 implementation, the ST relationship between carriage and IPD was investigated.

•In children <2 years old, 569 IPD and 355 Sp isolated from 1212 healthy were compared.

•Before PCV13, 5 serotypes: 7F, 3, 1, 24F, and 19A had high invasive disease potential.

•After PCV13, only 2 serotypes: 24F and 12F had high invasive disease potential.