Article de revue
New developments in dry powder pulmonary vaccine delivery
Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery.
Auteurs
Langues
- Anglais
Année de publication
2011
Journal
Trends in Biotechnology
Volume
4
Type
Article de revue
Catégories
- Vaccins et dispositifs d'administration
Mots-clés
- Introduction de nouveaux vaccins