Article de revue
Prevention of pneumococcal infection with vaccines
The first vaccines to prevent pneumococcal infections, crude preparations of killed bacteria, were developed by Sir Almroth Wright in 1911 to try to alleviate the high mortality and morbidity among gold miners in South Africa. Discovery that antibodies against purified polysaccharides of the capsular surface of pneumococci were protective led to development of polysaccharide vaccines that were marketed in the 1940s. These vaccines were commercial failures because the advent of antimicrobials led to a perception that pneumococcal infections were no longer a major threat.
Auteurs
Langues
- Anglais
Année de publication
2012
Journal
JAMA
Volume
8
Type
Article de revue
Catégories
- Vaccins et dispositifs d'administration
Maladies
- Infection à pneumocoque
Pays
- États-Unis
Mots-clés
- Introduction de nouveaux vaccins
Régions de l'OMS
- Région des Amériques