Journal article
Prevention of pneumococcal infection with vaccines
The first vaccines to prevent pneumococcal infections, crude preparations of killed bacteria, were developed by Sir Almroth Wright in 1911 to try to alleviate the high mortality and morbidity among gold miners in South Africa. Discovery that antibodies against purified polysaccharides of the capsular surface of pneumococci were protective led to development of polysaccharide vaccines that were marketed in the 1940s. These vaccines were commercial failures because the advent of antimicrobials led to a perception that pneumococcal infections were no longer a major threat.
Authors
Languages
- English
Publication year
2012
Journal
JAMA
Volume
8
Type
Journal article
Categories
- Vaccines & delivery devices
Diseases
- Pneumococcal disease
Countries
- United States
Tags
- New vaccine introduction
WHO Regions
- Region of the Americas